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Overproduction of ROS can destroy biological membranes, attack DNA, cause gene mutations and protein denaturation, and ultimately cause various human diseases, neurodegenerative diseases, carcinogenesis, and aging-related diseases ( 2.2 Mitochondrial ROS in hearing loss Mitochondria ROS overproduction plays a key role in cochlear damage and hearing impairment (Pryde and Hirst, 2011)

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