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10.1073/pnas.0909422107 [DOI] [PMC free article] [PubMed] 146.Denroche HC, Levi J, Wideman RD, Sequeira RM, Huynh FK, Covey SD, et al

When joints are inflamed, they produce excess reactive oxygen species (ROS), which include superoxide and hydrogen peroxide, to the point that they overwhelm the bodys defences and deplete the local glutathione supply [6]

pylori in human stomach parietal cells, hence inducing inflammation and gastric parietal cell carcinogenesis (127)

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Common routes of exposure include inhalation, dermal contact, and ingestion via commonly contaminated food sources (corn, cereals, ground and tree nuts, spices, dried fruits, apples, coffee, meat, milk, and eggs)

However, some results indicated that genetic mutations in the genes encoding copper efflux proteins ATP7A/B could lead to functional impairment, which might impair Cu + efflux within cells, copper overload, and induction of copper related cell death