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[PubMed 25891257] 3169
[DOI] [PubMed] [Google Scholar] 193.Niwa T
Safety Pharmacology studies assess potential effects of a new drug on physiological functions across a dose range that encompasses and surpasses therapeutic levels
Staying well-hydrated is essential, as these medications can influence fluid balance and potentially contribute to constipation
It is a relatively selective alpha-2 adrenergic receptor agonist
However, the close resemblance of human in vivo metabolism demonstrated by minipig systems clearly warrants further investigation with additional aromatic amide-containing compounds
