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Description
ADMET properties of lead compound (crocin) The ADMET profiles of crocin and troriluzole were evaluated using the admetSAR platform to assess their drug-likeness, safety, and pharmacokinetic behavior (Table S16)

The augmented generation of pyruvate via accelerated glycolysis under hyperglycemic conditions is thought to flood the mitochondria and thus generates formation at the level of Complex II in the respiratory chain (Nishikawa et al., 2000)

decrease fasting insulin and glucose levels Advantages are a significant increase in sex hormone-binding globulin (SHBG) and a decrease in total testosterone levels and the free androgen index (FAI), which can reduce symptoms like hirsutism (excess hair growth) and acne

SIDE EFFECTS Gastrointestinal disturbances such as bloating or cramping

Forming sperm cells

Rheumatology, 44 (7), 902906
