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A Possible Link between Iron Deficiency and Gastrointestinal Carcinogenesis

doi: 10.3109/13880209.2014.993041

Ferroptosis induces gut microbiota and metabolic dysbiosis in collagen-induced arthritis mice via PAD4 enzyme

CD73 inhibitors target the ectonucleotidase CD73, which catalyzes the conversion of AMP to immunosuppressive adenosine in the TME.Monoclonal antibodies such as oleclumab have entered clinical trials in NSCLC, aiming to restore T cell and NK cell cytotoxicity by blocking adenosine signaling [124]

YasirMSaraUVSChauhanIGaurPKSinghAPPuriDet alSolid lipid nanoparticles for nose to brain delivery of donepezil: formulation, optimization by boxbehnken design, in vitro and in vivo evaluation

RNA sequencing and RNAPII-ChIP-Seq analyses demonstrate triptolide's biphasic impact on gene expression in pancreatic cancer (MIA PaCa-2) cells and cancer-associated fibroblasts, highlighting transcriptional down-regulation and specific alterations in histone acetylation [1020, 1021]