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United States: International Institute of Anticancer Research (Dr

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TNF interacts strongly with the Fas ligand because it is a member of the Fas superfamily, and this interaction activates caspases, whose activity leads to apoptosis.[59] Following trauma, chemokines, including MIP-, MCP-1, and IL-8 (CXCL8), are greatly increased, working in concert to attract leukocytes to the lesion site further.[5,22,25,39,59] Astrogliosis is facilitated by persistent and delayed neuroinflammation, which also attracts macrophages and promotes the activation of local microglia.[39,59] Years after TBI, survivors can continue to exhibit a collection of macrophages and active microglia, which is indicative of phagocytosis and chronic inflammation

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