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**Lower cost** AOD-9604 was historically cheaper than GLP-1 medications However, the clinical reality is that AOD-9604 failed its pivotal weight loss trial

Lee et al., 2016a

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While one of these studies used SF as an adjunctive therapy, we posit that the method of delivery, SF, may be the key to minimizing differences in bioavailability and, consequently, achieving significant behavioral improvements

This safety profile has contributed to their common use as a pain management tool

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