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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

For Group 2 DEGs (WT-unique genes), the analysis did not identify any specific pathways

Intramuscular administration of aripiprazole lauroxil to rats and dogs was associated with injection site tissue reactions at all doses in rats treated up to 6 months at doses of 15, 29, and 103 mg/animal (which are approximately 0.3 to 2 times and 0.5 to 3 times the MRHD of 1064 mg on mg/m2 basis in males and females, respectively) and in dogs treated up to 9 months at doses of 147, 662, and 2058 mg/animal (which are approximately 0.5 to 6 times and 0.6 to 8 times the MRHD in males and females, respectively on mg/m2 basis)

Finer N (2022) Weight loss interventions and nonalcoholic fatty liver disease: optimizing liver outcomes

Manuscript source: Unsolicited manuscript Peer-review started: October 7, 2019 First decision: November 27, 2019 Article in press: January 19, 2020 Specialty type: Gastroenterology and hepatology Country of origin: Croatia Peer-review report classification Grade A (Excellent): 0 Grade B (Very good): 0 Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Dragoteanu MN S-Editor: Ma YJ L-Editor: A E-Editor: Wu YXJ Contributor Information Slaven Gojkovic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia

Dans la plupart de ces tudes, on n'a pas tudi la toxicit pour la mre