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Description
A pyridazine derivative LDN-212320, which appears to potentiate EAAT2 translation, demonstrated beneficial effects in SOD G93A mice 443 and improved cognitive performance in the APP Sw,Ind AD mouse model 444
This reduced blood flow can result in neurological dysfunction and the abnormal neuroimaging observed in ME/CFS (158)
In the presence of the ProteoStat dye (which binds and fluoresces in the presence of protein aggregates), fluorescence intensity was significantly increased in DJ1 L166P astrocytes, indicating an accumulation of protein aggregates (Fig
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doi:10.1016/j.fertnstert.2008.08.074
