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In fact, growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline (Jin et al., 2015)
This interaction is important for driving T cell polarization towards particular subsets, such as the T helper cells, which then further differentiate into Th1, Th2, Th17, or regulatory T cells (Tregs) (114)

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LLC, San Jose, CA, USA)
doi: 10.1002/mrd.23542 23 XuZKalbfleischJD

doi: 10.1002/art.41666 [DOI] [PMC free article] [PubMed] [Google Scholar] 95.Iwamoto N, Kawakami A