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The overexpression of -synuclein, which may play a role in the immune response [58], may then cause microglia to become active [59]
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Indeed, earlier studies reported that CR reduces the over production of ROS and oxidative damage, leading to enhanced mitochondrial function in humans and be an effective remedy for the treatment of obesity and insulin resistance [182-185]
[DOI] [PMC free article] [PubMed] [Google Scholar] 153.Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J
