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It is estimated to affect approximately 9.4% of the world population (171, 172)

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These studies suggest that the progression of cardiovascular disease can be limited by suppressing TMAO production and removing TMAO or its precursors, providing evidence for the evolution of future interventions targeting cardiac metabolic phenotype (Astudillo and Mayrovitz, 2021)

However, longitudinal receptor-desensitization models, sustained-exposure paradigms, and chronic transcriptomic investigations remain insufficiently explored within MC4 appetite-regulation research systems

Depending on results, treatment may involve using supplements such as coenzymes Q10, creatine, L-carnitine and folate