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Acknowledgements Research in the authors' laboratory is supported in part by the National Natural Science Foundation of China (N o 30873035) and the Key Project of the Foundation of Tianjin High Education Commission (N o ZD200714)

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The most common adverse events with CagriSema were gastrointestinal, and the vast majority were mild to moderate and diminished over time, consistent with the GLP-1 receptor agonist class