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Molecular glues function as CIPs without needing to bind the target and effector independently

In vitro, the mutant MOB1-K11R, which lacks acetylation, enhances the proliferation, migration and invasion of lung cancer cells, and in vivo, it accelerates tumor growth compared to wild-type MOB1 (105)

In others, acetylcysteine is also administered in a weight-adjusted, capsule-based, supplement

Another important contributing factor of CIPN is the neuroinflammation caused by an increased infiltration of immune cells and production of inflammatory cytokines

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Kras function implies an intervening capillary network, preventing highpressure arterial blood from feeding arteries to shunt directly into the venous outflow system (Nikolaev et al., 2018)