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Biomarkers of oxidative damage including malondialdehyde, F2-isoprostane, protein carbonyls and advanced glycation end products (AGE) are reported to be elevated in either the plasma, erythrocytes or liver of streptozotocin (STZ)-induced diabetic rats [228231], as well as in the plasma or urine of diabetic patients [232234], giving further evidence of ROS contribution to the onset, progression and pathological consequence of diabetes

In contrast to animals, NO production in plants occurs through multiple pathways, including both enzyme-dependent and enzyme-independent mechanisms

For parameter estimation, the maximum-likelihood approach is used

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Abstract The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs)