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Within this incretin-dominant environment, glucagon receptor activation may contribute more strongly to energy expenditure, fatty acid oxidation, and hepatic lipid metabolism than to uncontrolled hyperglycemia

Halliday et al

Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2 / mice by modulating composition, signalling and excretion of faecal bile acids

Anaphylactic shock and death have been reported after parenteral vitamin B12 administration in sensitive patients

ArakiKTurnerAPShafferVOGangappaSKellerSABachmannMFet al

But when combined with GLP-1 activity, the glucose-raising effect is neutralized while the energy expenditure benefits remain