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Mechanistically, circadian control of CI probably reflects the intersection of substrate routing and time-of-day coordination of CI biogenesis, stability and activity

DOI: 10.1038/nature24302 Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C.T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D.E., Strkel, P., Loomba, R., Coulter, S., Liddle, C., Yu, R.T., Ling, L., Rossi, S.J., DePaoli, A.M., Downes, M., Evans, R.M., Brenner, D.A., Schnabl, B

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Melatonin in mitochondria: mitigating clear and present dangers

identified two compounds, RAS-selective lethal 3/5 (RSL3/5), with similar properties to erastin (25)

In our biophysical characterisation assays (Supplementary Fig