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Challenges Clinical trials testing the effect of oral arginase inhibitors on endothelial function are currently not available, due perhaps to the fact that most oral formulations of arginase inhibitors have poor oral bioavailability (Pudlo et al., 2017)

PLoS One 15 , e0234001 (2020)

Integration of quartz crystal microbalance-dissipation and reflection-mode localized surface plasmon resonance sensors for biomacromolecular interaction analysis

Additionally, they point out that hyperhomocysteinemia remains an independent risk factor for thrombosis and stroke after adjustment for established risk factors

In addition, OS in the central nervous system (CNS) may seriously damage the brain via several interacting mechanisms, including an increase in intracellular free Ca 2+ , release of excitatory amino acids, and neurotoxicity (4)

Trijau M, Asselman J, Armant O, Adam-Guillermin C, De Schamphelaere KAC, Alonzo F (2018) Transgenerational DNA methylation changes in Daphnia magna exposed to chronic irradiation
