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An integrated perspective now links these viewpoints: intrinsic CNS vulnerabilities, such as astroglial metabolic stress, mitochondrial dysfunction and abnormal antigen presentation, may prime the immune system, while systemic immune dysregulation breaches the bloodbrain barrier (BBB) and amplifies damage

The Journal of Frailty & Aging, 8 (3),154-159

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Many people who suffer from brain fog may be dealing with underlying nutrient deficiencies, including low levels of B12

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These findings were corroborated in a mouse model of CMV infection under conditions of immunosuppression