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Description
Gambogic acid eliminates lactylation of CNPY3, altering its localization and recruiting SIRT1, which activates caspase-1 and gasdermin D (GSDMD) through lysosomal rupture and cathepsin B (CatB) release, ultimately triggering pyroptosis in PCa cells

doi: 10.1056/NEJMoa1710504

Annual Review of Public Health , 34 (1), 337354
& Magistretti, P

[DOI] [PubMed] [Google Scholar] 19.Zhu D., Pham Q.M., Wang C., Colonnello E., Yannas D., Nguyen B.H., Zhang Y., Jannini E.A., Sansone A

Treatment of atopic dermatitis (eczema)
