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Sci Rep 7: 8009, 2017

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Clearance is related to the total drug concentration in the plasma (free + protein-bound) and not the free concentration

Since M2 macrophages consume more glutamine than M1 macrophages, in the TME, it is unclear whether inhibiting the anti-tumor immune response from M2 macrophages polarization would be greater than the effect of enhancing the anti-tumor immune response from the M1 macrophages

10.1007/s10571-015-0166-x 112 LiS.ZhaoH.WangY.ShaoY.WangB.WangY.et al (2018)

It is estimated that glutamine accounts for approximately 4.7% of all amino acid residues in human proteome, while in select proteins, for instance, in the structural component of skin epidermal barrier, involucrin, the representation of glutamine residues can reach 25%