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It reduces the activity of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), two key enzymes in the de novo lipogenesis pathway

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79 Dietary-derived octadecanoids therefore appear to participate in a feedback system in which the gut microbiome converts dietary fatty acids into octadecanoid lipid mediators that attenuate obesity

The Neh2 domain, which contains ETGE and DLG motifs, is pivotal for Keap1 binding and ubiquitination, whereas the Neh1 domain features a basic leucine zipper (bZIP) structure essential for DNA binding and dimerization with small Maf proteins [17]

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