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A major limitation of metabolomics is the great heterogeneity associated with the biological composition of distinct metabolites

Importantly, studies interrogating the effects of drug exposure on both expression and function suggest that increased expression does not necessarily correlate with functional readouts of receptor activity

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When searching for potential biomarkers of disease status, it was determined that individuals with konzo did have a higher incidence of albumin carbamoylation, a post-translational modification likely induced by increased exposure to a toxic byproduct of linamarin degradation, cyanate 29

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