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10.1016/j.neulet.2015.01.048 42 CataJ

Key pathways such as PI3K/AKT/mTOR (PAM), RAS/RAF/MEK/ERK [22], and Notch are frequently activated in GBM, promoting cell proliferation, survival, and invasion, while also contributing to the resistance of GBM cells to chemotherapy and radiation therapy

Each cell was cultured until a visible clone was observed and then expanded on six-well culture plates

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MOTS-c's AMPK activation aligns with the body's metabolic circadian rhythm, which peaks in the morning and early afternoon