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Here, we observed that during early infection this extends to other strains exhibiting strong cytotoxicity on HEK293A cells

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It is, in fact, highly effective to exploit its own programmed cell death mechanism ( 3.1 Intrinsic pathway The intrinsic pathway of apoptosis is caused by a range of physical and chemical stimuli with hypoxia, deprivation of growth factors, and other types of cellular stimuli including excess calcium ions (Ca 2+ ), cellular detachment, and many stress signals including DNA damage, oncogene activation, oxidative stress, and irradiation ( This intrinsic pathway starts with the upregulation of BH3-only proteins leading to the attachment of pro-apoptotic proteins (Bax, Bak) into the mitochondrial membrane through their oligomerization triggers mitochondrial outer membrane permeabilization (MOMP), and subsequently, the liberation of cytochrome c from the intermembrane space into the cytosol