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Breast cancer, risk of death at 1 year down (13 studies but no information on total number of subjects) Nocturnal hypertension, systolic and diastolic, down (3/72) Sleep latency down (5/2234) Sleep duration up (4/2417), largest study significant for latency as above but non-significant for duration) Melatonin onset (DLMO) (6/238) Core temperature down (16/193) A meta-analysis of the protective effects of melatonin in ischemic stroke in rodents is included with 432 animals and a highly significant large effect size

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Some of these investigations are also testing interventional strategies, such as melatonin supplementation or circadian-friendly lighting systems, to mitigate biological disruptions in NS workers 30

The CJC + Ipamorelin stack wins on effect size