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Description
This method is used to determine regions of rigid atomic packing, but does not take into account sites that are too susceptible to solvent (sites located on the surface of the molecule)

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Heliyon, 9 (7), e18288
Basic pharmacokinetic principles and their application to psychotropic drugs

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They should therefore not be able to carry out deglutathionylation steps and may have different substrates or reaction mechanisms
