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Pediatr Res (2006) 59:5849

doi:10.1038/nrm3028 pmid:21179058 Zhang T, Tsutsuki H, Islam W, Ono K, Takeda K, Akaike T, Sawa T (2021) ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

These criteria include appropriate affinity for the target antigen, minimal or absent binding to off-target sites, and the ability to efficiently penetrate and internalize within tumor cells [44]

Notably, targeting mitochondrial pathologies are often mired by efficacy-limiting unintended off-target effects [22]