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They have identified specific cell surface markers and functional properties that distinguish Bregs from other B cell subsets, which helps in understanding their unique regulatory functions ( Establishing the existence of one or multiple subsets of Bregs has been challenging due to the absence of specific markers that are analogous to the Treg marker FoxP3 ( Specific markers for Bregs include (1)

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This is consistent with the passage of microbial substances to the systemic circulation and the activation of inflammatory pathways

Furthermore, DSIP has the ability to alter the serum levels of some hormones , such as corticotropin, somatostatin, serotonin, etc

Hepatology 40 , 972980 (2004)

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