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rather, there was a trend toward worse survival in the treatment groups (Fig
Treating N1IC cells with IACS-010759, a specific complex I inhibitor, decreased total ROS production as well as cellular and mitochondrial lipid peroxidation (Fig
Goodall M, Thorburn A
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Endo, Y
In summary, these studies highlight microglial polarization modulation as a central therapeutic approach in PD, targeting both inflammatory response and iron-dependent oxidative damage to confer neuroprotection
