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Interestingly, DMF is also shown to regulate ferroptosis in a time-dependent manner, inducing ferroptosis in a short period but repressing ferroptosis in a long period 58

The remaining six studies were conducted at 7T in the following ROIs: corona radiata white matter (WM) (van de Bank et al., 2015), and the cingulate (medial pregenual anterior, posterior) (Gonen et al., 2020, Lally et al., 2016, van de Bank et al., 2015), occipital (Prinsen et al., 2017), precuneal (Gonen et al., 2020), motor (Lim and Xin, 2022), medial prefrontal (Lim and Xin, 2022) and/or the dorsolateral prefrontal (Reid et al., 2022) cortices

In addition to its direct antioxidant functions, glutathione (GSH) contributes to the regeneration of other antioxidants, including vitamins C and E, and is involved in critical processes such as iron homeostasis and mitochondrial integrity

Without enough mitochondrial capacity to burn those fatty acids efficiently, they get recirculated and re-deposited, or worse, they overwhelm tissues that cant handle the load (a process called lipotoxicity)

doi: 10.3390/pharmaceutics15071796

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