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Proteomic analysis of covalent modifications of tubulins by isothiocyanates

A reproduction study in Stride Dutch rabbits revealed cranioschisis in 7 of 19 (37%) fetuses at 50 mg/kg, corresponding to 250 times the maximum nebulization dose for a 50 kg human

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Sauerbrei A, Deinhardt S, Zell R, Wutzler P

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Notably, induction of heat responsive genes by AITC was often more than 10-fold stronger than after treatment with SF, BITC, or PGA 1 (Table 1) which might be due to structural differences, higher dosage or longer exposure time