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[6] The reaction mechanism of the P-450 oxidases proceeds through the reduction of cytochrome-bound oxygen and the generation of a highly-reactive oxyferryl species, according to the following scheme: [7] Phase II - conjugation [edit] In subsequent phase II reactions, these activated xenobiotic metabolites are conjugated with charged species such as glutathione (GSH), sulfate, glycine, or glucuronic acid

suggests that ZnT1, which exports zinc from cells, may also be involved in copper uptake and cuproptosis

Liao, Y

LC-ESI-QTOF method for the targeted metabolomics analysis The samples were analyzed by a 1290 Infinity II LC instrument coupled to a 6546 LC/Q-TOF high-resolution mass spectrometer, and the ionization was performed using a Dual Jet Stream source in negative mode (Agilent Technologies, Waldbronn, Germany)