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This isn't a minor detail

[DOI] [PMC free article] [PubMed] [Google Scholar] 110.Noctor G., Foyer C.H

It leverages large-scale databases such as TCMSP, STITCH, STRING, GeneCards, and OMIM to construct compound target pathway networks, helping researchers identify hub genes, key targets, and synergistic interactions

But, the biggest impact is on skin sensitivity

Not necessarily, and thats intentional

Toxicity induced by multiple high doses of vitamin B(12) during pernicious anemia treatment: a case report
