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Among the emerging therapeutic strategies to reduce oxidative stress in ALD, several studies have shown the beneficial effect of folate, betaine, and metadoxine administration

References Rivier J, Spiess J, Thorner MO, Vale W

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Both treatments increased serum adiponectin and insulin sensitivity, and improved testosterone and FSH levels

The importance of this finding is highlighted by the fact that GWAS utilizes a less biased approach by first detecting, among a large pool of candidate SNPs, those SNPs that strongly correlate with disease risk or progression