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Cellular senescence: All roads lead to mitochondria

These cells secrete neurotrophic factors like brain-derived neurotrophic factor (BDNF) to promote synaptic remodeling, addressing synaptic dysfunction in neurodegenerative diseases

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Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer

It was first proposed by Brent Stockwells team in 2012 [12]

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