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tGSH levels were (a) significantly decreased in young relative to old adults (Nuttall et al., 1998), (b) significantly decreased in young adults (2735 yrs) compared to young to middle-aged (3657 yrs) (Kretzschmar et al., 1991), while (c) no significant differences were observed between middle-aged to old (5570 yrs) and old (7085 yrs) adults (Andriollo-Sanchez et al., 2005)

These phenomena are thus analogous and correspond to the well-known downregulation of receptors for LH-RH 3 , induced by therapy with agonistic analogs of LH-RH 3

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