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Disrupting the p53-FOXO4 interaction using FOXO4-DRI caused p53 to be excluded from nucleus and directed to mitochondria for induction of apoptosis, ultimately eliminating the senescent cells

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According to previous studies, Clostridiaceae , Dialister , Clostridium , Erysipelotrichaceae , Lachnoclostridium , and Subdoligranulum are decreased in AD patients, whereas Blautia, Phascolarctobacterium, Gemella, Bacteroides, Alistipes, Odoribacter , and Barnesiella are increased [327,328,329]

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