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Preclinical studies have confirmed that IMD-0354 significantly suppresses the growth of melanoma and hepatocellular carcinoma (HCC) through competitive inhibition of SLC1A5 (152, 153)

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An interesting observation is that three Cu 2+ containing groups (ZC, CQ, and ZCQ) showed higher stimulatory effect as compared to ZQ group, indicating the specific role of Cu 2+ on the activation of HUVECs
