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Together, these observations lead to the conclusion that the formation of NAPQI by Cyp2E1 and the formation of protein adducts, especially on mitochondria, are initiating events leading to mitochondrial dysfunction and mitochondrial oxidant stress (Fig

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Clinical Study on Crystal Tomato Whitening Supplement In 2013, a study conducted by the National Skin Centre in Singapore found that Crystal Tomato Whitening Supplement significantly reduced the Modified Melasma Area Severity Index (mMASI) and melanin index of 44 melasma patients compared to the placebo group, which received the standard "Triple Topical Therapy." These results indicate that the supplement may help lighten melasma and reduce pigmentation, offering a more natural option for managing hyperpigmentation
