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Increasing evidence has demonstrated that in response to hypoxia, tubular epithelial cells undergo changes and function as inflammatory and fibrogenic cells (they may undergo tubular epithelial cell death/atrophy, maladaptive repair, metabolism switch, senescence, etc.), with the consequent production of various bioactive molecules that drive interstitial inflammation and fibrosis
[DOI] [PubMed] [Google Scholar] 65

Strekalova 1998

D.PopkoB

Recommendations: Start with lower doses than standard protocols suggest