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[DOI] [PubMed] [Google Scholar] Liang W, Fishman PH

The angiotensin II type 1 receptor-neprilysin inhibitor LCZ696 blocked aldosterone synthesis in a human adrenocortical cell line

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Int J Biol Markers 33(1):94101

Our early studies demonstrated that vascular dysfunction of epineural arterioles that provide circulation to the sciatic nerve preceded slowing of nerve conduction velocity in streptozotocin-induced diabetes ( Studies in both types 1 and 2 diabetic rats have demonstrated that impaired vascular relaxation of the small blood vessels that provide circulation to the sciatic nerve occurs prior to the development of nerve dysfunction such as slowing of motor nerve conduction velocity ( AVE7688 & LCZ7696 After a series of studies our interest turned to a combination therapy consisting of inhibition of angiotensin converting enzyme (ACE) and NEP or neprilysin