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and (4) injury to the kidney and small intestine from reperfusion following ischemic events

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doi: 10.1016/j.aca.2008.05.001

A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action

Mechanistically, CAT promotes ubiquitination and proteasomal degradation of HIF-1, thereby attenuating osteoclast differentiation and bone resorption (Figure 4)

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