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Funding The work reported in this manuscript was supported by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH) under award number R01GM1277871 (to GRR) and R35GM136312 (to KAS)

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Carbohydrate are broken down into glucose, which is then further broken down into acetyl-CoA for ATP production in the mitochondria

Several observational studies indicated a relationship between carnitine system and lipid metabolic problems in Parkinson's disease patients (Marn VB, Azocar M, Molina M, Guerrero JL, Ratner R, 2006)

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Furthermore, administration of L-carnitine substantially altered the effects of TRZ and markedly reduced the expression of autophagy-related genes such as Beclin1, Autophagy Related Gene 5 (ATG5), and the inflammatory mediator TNF- in comparison to the TRZ treated group (Khedr et al