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Description
A deficiency in B12 can increase susceptibility to infections and cause general fatigue
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Oral supplements are easy but require discipline

The core concept is that normal components of the tissue (or of the niche where the tumor grows) may provide, either occasionally or as part of a precise neoplastic strategy, a set of soluble factors that contribute to, or even determine, the growth of the tumor itself or facilitate immune evasion
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Both refer to the same naturally occurring copper peptide