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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

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Molecular evidence was established by quantifying the expression levels of Ki-67, CD98hc, caspase-3, and MMP-9 in fibroblasts treated with AEDG [53]

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The authors describe this bill of rights as a call to action for researchers in Alzheimer's disease and related dementias to proactively design clinical studies that provide the option for research participants to learn their individual research results if they choose, and in a manner that ensures study integrity

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