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In the four-component Ugi reaction, the five different isocyanide derivatives of 4-hydroxythalidomide, in the presence of tritylamine or methylamine, formaldehyde, and acid-containing derivative of the target ligand (JQ1 derivative) yielded different anti-BRD4 PROTACs 178

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The discussion of potential translational trials and the remaining challenging in this field will also be presented

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Pappas, C

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