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AOD 9604 targets fat cells directly through beta-3 adrenergic receptor activation

[DOI] [PMC free article] [PubMed] [Google Scholar] 238.Folpe AL

To demonstrate that suppression of p70S6K protein and pNPM1 by RSL3 is GPX4 inhibition-specific in PTC cells, we treated K1 cells with RSL3 (3 M) in the presence of ferrostatin-1 (5 M), an effective inhibitor of ferroptosis and analyzed by Western blotting

We take the reaction to have standard bi-bi kinetics with K m = 97 M for APAP [24] and K m = 5

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Its capacity to neutralize reactive oxygen species (ROS) helps protect nerve cells from oxidative stress, a key factor in aging and neuro-degenerative conditions (, )