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Secondly, in order to preserve residual mitochondrial bioenergetics and positively regulate the body homeostasis/adaptation capacities of these patients, the manuscript will put forward an innovative therapeutic view for the management of the disease, based on a diet with a moderate intake of carbohydrates and enriched in proteins, the practice of exercises of suitable type and intensity and a potential use of dietary supplements (Table 1)

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Setmelanotide is a MC4R-selective disulfide-cyclized octapeptide that incorporates several noncanonical amino acids ( Figure 2 ) (78)

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