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Epigenetic mechanisms further exacerbate this: hypoxia, a key pathological process in endometriosis, upregulates histone methyltransferase EZH2, which catalyzes H3K27Me3 modification at the IGFBP1 promoter, suppressing this critical decidual marker and directly impairing decidualization (49)

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doi: 10.1016/S0022-1910(00)00125-6

Sato K, Takigawa N, Kubo T, et al

[Abstract] KA treatment: Lidocaine (3%) and KA (2 mg/mL) were infused bilaterally into the LC via delivery cannulas connected to the cannula drug delivery system in a 0.2 L volume per side at a rate of 0.1 L/10 s 30 min after training

Opioid peptides and control of human ingestivebehaviour